Endocrine Abstracts

Background: Adults with GH deficiency (GHD) may have an increased risk of cardiovascular disease. Several studies showed that also GHD children may present cardiovascular risk factors. However results are controversial.Objective: Aim of this prospective, case-control study on a large cohort of children with GHD was to evaluate the effects of GHD and GH therapy on cardiovascular risk factors, such as lipid profile, clinical measures of visceral adiposity ...

Recently it has been shown that somatostatin (SST) might be of therapeutic value in the treatment of active Graves’ophthalmopathy (GO). SST and somatostatin receptors (sst) transcripts are expressed and functional in cultured orbital fibroblasts deriving from GO patients (FGO). Octreotide, the SST analogue currently used is able to inhibit in vitro growth and activity of FGO. New analogues with wider sst-affinity are now available for in vitro experim...

Autoimmune chronic thyroid disease (AITD) is associated with atrophic gastritis (CAG) in 29–42% of the cases. CAG and the consequent hypergastrinemia, listed as precancerous lesion, can predispose to neuroendocrine cells hyperplasia and the development of neuroendocrine gastric tumors (NET). Aim of this study was to evaluate the association of AITD with risk of gastric NET and the efficacy of somatostatin analogues treatment.Patients: From 2009 to 2...